Version 5.4
Mus musculus Gene: Lasp1
Summary
InnateDB Gene IDBG-210370.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lasp1
Gene Name LIM and SH3 protein 1
Synonyms AA408629; Def-4; SH3P6; Tg(Col1a1-lacZ)1Ngma
Species Mus musculus
Ensembl Gene ENSMUSG00000038366
Encoded Proteins
IDBP-210372
LIM and SH3 protein 1
IDBP-531833
LIM and SH3 protein 1
IDBP-623568
LIM and SH3 protein 1
IDBP-538500
LIM and SH3 protein 1
IDBP-537229
LIM and SH3 protein 1
IDBP-537256
LIM and SH3 protein 1
IDBP-538660
LIM and SH3 protein 1
IDBP-541224
LIM and SH3 protein 1
IDBP-535061
LIM and SH3 protein 1
IDBP-534799
LIM and SH3 protein 1
IDBP-539040
LIM and SH3 protein 1
IDBP-534704
LIM and SH3 protein 1
IDBP-541252
LIM and SH3 protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000002834:
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:97799000-97838764
Strand Forward strand
Band D
Transcripts
ENSMUST00000043843 ENSMUSP00000042123
ENSMUST00000107569
ENSMUST00000107568
ENSMUST00000143571 ENSMUSP00000116102
ENSMUST00000127033 ENSMUSP00000127792
ENSMUST00000129558 ENSMUSP00000123165
ENSMUST00000152962 ENSMUSP00000120645
ENSMUST00000146572 ENSMUSP00000121907
ENSMUST00000136723 ENSMUSP00000114306
ENSMUST00000134428 ENSMUSP00000119797
ENSMUST00000129828 ENSMUSP00000115308
ENSMUST00000148280 ENSMUSP00000123050
ENSMUST00000138919 ENSMUSP00000114407
ENSMUST00000153520 ENSMUSP00000120458
ENSMUST00000155762 ENSMUSP00000119538
ENSMUST00000127575
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0015075 ion transmembrane transporter activity
GO:0051015 actin filament binding
Biological Process
GO:0006811 ion transport
GO:0034220 ion transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0030864 cortical actin cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000002834
View Gene Order
ENSBTAG00000030587
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.271967 Mm.470698
RefSeq NM_010688 XM_006532341 XM_006532342
OMIM
CCDS CCDS25332
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca