InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Snta1

Summary

InnateDB Gene

IDBG-210373.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Snta1

Gene Name

syntrophin, acidic 1

Synonyms

AW228934; Snt1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027488

Encoded Proteins

IDBP-210375

syntrophin, acidic 1

IDBP-261768

syntrophin, acidic 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101400:
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:154376313-154408099

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028991	ENSMUSP00000028991
ENSMUST00000109728	ENSMUSP00000105350
ENSMUST00000133018

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0017080	sodium channel regulator activity
GO:0030165	PDZ domain binding
GO:0044325	ion channel binding
GO:0050998	nitric-oxide synthase binding
GO:0051117	ATPase binding

Biological Process

GO:0002027	regulation of heart rate
GO:0003117	regulation of vasoconstriction by circulating norepinephrine
GO:0007528	neuromuscular junction development
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
GO:0086005	ventricular cardiac muscle cell action potential
GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation
GO:1902305	regulation of sodium ion transmembrane transport

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0030054	cell junction
GO:0031594	neuromuscular junction
GO:0042383	sarcolemma
GO:0043234	protein complex
GO:0045211	postsynaptic membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000101400

View Gene Order

ENSBTAG00000000512

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

p38gammadeltapathway

Signaling mediated by p38-gamma and p38-delta

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.1541

RefSeq

NM_009228

OMIM

CCDS

CCDS50763

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas