InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ppp1r1b

Summary

InnateDB Gene

IDBG-210547.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp1r1b

Gene Name

protein phosphatase 1, regulatory (inhibitor) subunit 1B

Synonyms

AU040756; DARPP-32; Darpp32

Species

Mus musculus

Ensembl Gene

ENSMUSG00000061718

Encoded Proteins

IDBP-210549

protein phosphatase 1, regulatory (inhibitor) subunit 1B

IDBP-539455

protein phosphatase 1, regulatory (inhibitor) subunit 1B

IDBP-535505

protein phosphatase 1, regulatory (inhibitor) subunit 1B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131771:
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:98348404-98357796

Strand

Forward strand

Band

Transcripts

ENSMUST00000078694	ENSMUSP00000077760
ENSMUST00000150762	ENSMUSP00000121147
ENSMUST00000137634	ENSMUSP00000123528
ENSMUST00000132443
ENSMUST00000147415
ENSMUST00000133700
ENSMUST00000152525

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004864	protein phosphatase inhibitor activity
GO:0004865	protein serine/threonine phosphatase inhibitor activity
GO:0031748	D1 dopamine receptor binding
GO:0031749	D2 dopamine receptor binding
GO:0031750	D3 dopamine receptor binding
GO:0031751	D4 dopamine receptor binding
GO:0031752	D5 dopamine receptor binding

Biological Process

GO:0001975	response to amphetamine
GO:0006351	transcription, DNA-templated
GO:0007165	signal transduction
GO:0007621	negative regulation of female receptivity
GO:0008542	visual learning
GO:0035556	intracellular signal transduction
GO:0043086	negative regulation of catalytic activity