Mus musculus Gene: Rgs10
Summary
InnateDB Gene IDBG-210654.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rgs10
Gene Name regulator of G-protein signalling 10
Synonyms 2310010N19Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000030844
Encoded Proteins
regulator of G-protein signalling 10
regulator of G-protein signalling 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148908:
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:128373621-128418758
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000033133 ENSMUSP00000033133
ENSMUST00000134144
ENSMUST00000129144
ENSMUST00000129120
ENSMUST00000145739
ENSMUST00000147840 ENSMUSP00000122030
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043679 axon terminus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
GPCR downstream signaling pathway
Signaling by GPCR pathway
G alpha (i) signalling events pathway
Signal Transduction pathway
KEGG
INOH
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
G alpha (i) signalling events pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Signaling by GPCR pathway
G alpha (i) signalling events pathway
Signal Transduction pathway
GPCR downstream signaling pathway
KEGG
INOH
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.18635
RefSeq NM_026418
OMIM
CCDS CCDS21896
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas