Version 5.4
Mus musculus Gene: Cdc6
Summary
InnateDB Gene IDBG-210829.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdc6
Gene Name cell division cycle 6
Synonyms CDC18L
Species Mus musculus
Ensembl Gene ENSMUSG00000017499
Encoded Proteins
IDBP-210831
cell division cycle 6 homolog (S. cerevisiae)
IDBP-210835
cell division cycle 6 homolog (S. cerevisiae)
IDBP-539017
cell division cycle 6 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000094804:
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:98907801-98923940
Strand Forward strand
Band D
Transcripts
ENSMUST00000092706 ENSMUSP00000090382
ENSMUST00000093937 ENSMUSP00000091469
ENSMUST00000133779 ENSMUSP00000118421
ENSMUST00000135862
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0017111 nucleoside-triphosphatase activity
GO:0019900 kinase binding
Biological Process
GO:0006260 DNA replication
GO:0007067 mitotic nuclear division
GO:0008152 metabolic process
GO:0030071 regulation of mitotic metaphase/anaphase transition
GO:0032467 positive regulation of cytokinesis
GO:0051984 positive regulation of chromosome segregation
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005819 spindle
GO:0051233 spindle midzone
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000094804
View Gene Order
ENSBTAG00000010384
Not yet available
Pathways
NETPATH
REACTOME
REACT_249770
Cell Cycle, Mitotic pathway
REACT_258062
Synthesis of DNA pathway
REACT_244558
CDT1 association with the CDC6:ORC:origin complex pathway
REACT_232628
DNA Replication pathway
REACT_262530
Switching of origins to a post-replicative state pathway
REACT_199110
G0 and Early G1 pathway
REACT_249922
CDK-mediated phosphorylation and removal of Cdc6 pathway
REACT_188804
Cell Cycle pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_259974
CDC6 association with the ORC:origin complex pathway
REACT_255479
Regulation of DNA replication pathway
REACT_254983
Activation of the pre-replicative complex pathway
REACT_245230
Orc1 removal from chromatin pathway
REACT_245528
M/G1 Transition pathway
REACT_235397
G2/M Checkpoints pathway
REACT_262002
Association of licensing factors with the pre-replicative complex pathway
REACT_253002
G1/S Transition pathway
REACT_236939
Removal of licensing factors from origins pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_198608
G1/S-Specific Transcription pathway
REACT_232236
Activation of ATR in response to replication stress pathway
REACT_206830
E2F mediated regulation of DNA replication pathway
REACT_235483
DNA Replication Pre-Initiation pathway
REACT_230841
Assembly of the pre-replicative complex pathway
REACT_253623
S Phase pathway
KEGG
mmu04110
Cell cycle pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_1221
CDK-mediated phosphorylation and removal of Cdc6 pathway
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_1181
Association of licensing factors with the pre-replicative complex pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_1707
CDC6 association with the ORC:origin complex pathway
REACT_1949
CDT1 association with the CDC6:ORC:origin complex pathway
REACT_2243
Assembly of the pre-replicative complex pathway
REACT_111214
G0 and Early G1 pathway
REACT_683
G1/S-Specific Transcription pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_828
G2/M Checkpoints pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_829
Regulation of DNA replication pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa04110
Cell cycle pathway
INOH
PID NCI
e2f_pathway
E2F transcription factor network
atr_pathway
ATR signaling pathway
Cross-References
SwissProt O89033
TrEMBL
UniProt Splice Variant
Entrez Gene 23834
UniGene Mm.20912 Mm.404059
RefSeq NM_011799 NM_001025779 XM_006533276
OMIM
CCDS CCDS25367 CCDS25368
HPRD
IMGT
MGI ID MGI:1345150
MGI Symbol Cdc6
EMBL AJ009559 AJ223087 AK012192 AK085020 AK166003 BC052434
GenPept AAH52434 BAB28090 BAC39341 BAE38512 CAA08752 CAA11110
RNA Seq Atlas 23834

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca