InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Jph2

Summary

InnateDB Gene

IDBG-211863.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Jph2

Gene Name

junctophilin 2

Synonyms

1110002E14Rik; JP-2; Jp2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000017817

Encoded Proteins

IDBP-211865

junctophilin 2

IDBP-262413

junctophilin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149596:
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:163336242-163397993

Strand

Reverse strand

Band

Transcripts

ENSMUST00000017961	ENSMUSP00000017961
ENSMUST00000109425	ENSMUSP00000105052

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0010314	phosphatidylinositol-5-phosphate binding
GO:0015278	calcium-release channel activity
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0070273	phosphatidylinositol-4-phosphate binding
GO:0070300	phosphatidic acid binding
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding

Biological Process

GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007275	multicellular organismal development
GO:0055024	regulation of cardiac muscle tissue development
GO:0055074	calcium ion homeostasis
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0030018	Z disc
GO:0030314	junctional membrane complex
GO:0033017	sarcoplasmic reticulum membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000149596

View Gene Order

ENSBTAG00000023002

Not yet available

Cross-References

SwissProt

Q9ET78

TrEMBL

UniProt Splice Variant

Entrez Gene

59091

UniGene

Mm.34459

RefSeq

NM_001205076 NM_021566

OMIM

CCDS

CCDS17008

HPRD

IMGT

MGI ID

MGI:1891496

MGI Symbol

Jph2

EMBL

AB024447 AB024448 AK157145 AL589876

GenPept

BAB12044 BAB12045 BAE33978 CAM13817

RNA Seq Atlas

59091