Mus musculus Gene: Sirt3 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-211875.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Sirt3 | ||||||||||||||||||||||
Gene Name | sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae) | ||||||||||||||||||||||
Synonyms | 2310003L23Rik; AI848213; Sir2l3 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000025486 | ||||||||||||||||||||||
Encoded Proteins |
sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)
sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)
sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)
sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)
sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142082:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 7:140863670-140882309 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | F5 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 95 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Organelle biogenesis and maintenance pathway
Mitochondrial biogenesis pathway
Transcriptional activation of mitochondrial biogenesis pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI |
Signaling events mediated by HDAC Class III
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | D3YVQ5 D3YWD6 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 64384 | ||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | XM_006536222 XM_006536223 NM_001127351 NM_001177804 NM_022433 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS21989 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:1927665 | ||||||||||||||||||||||
MGI Symbol | Sirt3 | ||||||||||||||||||||||
EMBL | AC107815 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 64384 | ||||||||||||||||||||||