Version 5.4
| Mus musculus Gene: Wisp2 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-211971.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Wisp2 | ||||||||
| Gene Name | WNT1 inducible signaling pathway protein 2 | ||||||||
| Synonyms | Ccn5; Crgr4; Ctgfl; Rcop1 | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000027656 | ||||||||
| Encoded Proteins |
WNT1 inducible signaling pathway protein 2
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000064205:
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008] This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72%% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 2:163820861-163833146 | ||||||||
| Strand | Forward strand | ||||||||
| Band | H3 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | A2AHD1 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 22403 | ||||||||
| UniGene | Mm.13828 | ||||||||
| RefSeq | NM_016873 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS17016 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:1328326 | ||||||||
| MGI Symbol | Wisp2 | ||||||||
| EMBL | AL731698 CH466551 | ||||||||
| GenPept | EDL06353 | ||||||||
| RNA Seq Atlas | 22403 | ||||||||