Version 5.4
Mus musculus Gene: Rnd2
Summary
InnateDB Gene IDBG-212215.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnd2
Gene Name Rho family GTPase 2
Synonyms Arhn; Rohn
Species Mus musculus
Ensembl Gene ENSMUSG00000001313
Encoded Proteins
IDBP-212217
Rho family GTPase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108830:
This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:101464999-101471853
Strand Forward strand
Band D
Transcripts
ENSMUST00000001347 ENSMUSP00000001347
ENSMUST00000153185
ENSMUST00000134980
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0048672 positive regulation of collateral sprouting
Cellular Component
GO:0002080 acrosomal membrane
GO:0005622 intracellular
GO:0005769 early endosome
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108830
View Gene Order
ENSBTAG00000007393
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
plexind1_pathway
Plexin-D1 Signaling
Cross-References
SwissProt Q9QYM5
TrEMBL A1L0U2 A2A4Q3 A2VCR8 Q8C6C0
UniProt Splice Variant
Entrez Gene 11858
UniGene
RefSeq NM_009708
OMIM
CCDS CCDS25473
HPRD
IMGT
MGI ID MGI:1338755
MGI Symbol Rnd2
EMBL AB017787 AF016482 AK075970 BC127034 BC128475 BC139330 BC139331 CH466558
GenPept AAB68844 AAI27035 AAI28476 AAI39331 AAI39332 BAA76545 BAC36087 EDL34052
RNA Seq Atlas 11858

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca