Mus musculus Gene: Wfdc8
Summary
InnateDB Gene IDBG-212251.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wfdc8
Gene Name WAP four-disulfide core domain 8
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000070533
Encoded Proteins
WAP four-disulfide core domain 8
WAP four-disulfide core domain 8
WAP four-disulfide core domain 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158901:
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains a Kunitz-inhibitor domain, in addition to three WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Two alternatively spliced transcript variants have been found for this gene, and they encode the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:164596458-164613626
Strand Reverse strand
Band H3
Transcripts
ENSMUST00000094351 ENSMUSP00000091911
ENSMUST00000109339 ENSMUSP00000104963
ENSMUST00000109338 ENSMUSP00000104962
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0008150 biological_process
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt Q4KUS1
TrEMBL
UniProt Splice Variant
Entrez Gene 277343
UniGene Mm.383292 Mm.400657
RefSeq NM_001080550 NM_001276431 NM_001276432 XM_006499671 XM_006499672 XM_006499673 XM_006499674 XM_006499675
OMIM
CCDS CCDS38324 CCDS71191 CCDS71192
HPRD
IMGT
MGI ID MGI:2685552
MGI Symbol Wfdc8
EMBL AL591478 AY757956
GenPept AAU93641 CAM15022
RNA Seq Atlas 277343