Version 5.4
Mus musculus Gene: Nbr1
Summary
InnateDB Gene IDBG-212256.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nbr1
Gene Name neighbor of Brca1 gene 1
Synonyms mKIAA0049
Species Mus musculus
Ensembl Gene ENSMUSG00000017119
Encoded Proteins
IDBP-212258
neighbor of Brca1 gene 1
IDBP-212260
neighbor of Brca1 gene 1
IDBP-212264
neighbor of Brca1 gene 1
IDBP-267127
neighbor of Brca1 gene 1
IDBP-267129
neighbor of Brca1 gene 1
IDBP-267131
neighbor of Brca1 gene 1
IDBP-267133
neighbor of Brca1 gene 1
IDBP-539900
neighbor of Brca1 gene 1
IDBP-619955
neighbor of Brca1 gene 1
IDBP-537294
neighbor of Brca1 gene 1
IDBP-619956
neighbor of Brca1 gene 1
IDBP-538477
neighbor of Brca1 gene 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188554:
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:101552149-101581951
Strand Forward strand
Band D
Transcripts
ENSMUST00000103099 ENSMUSP00000099388
ENSMUST00000103098 ENSMUSP00000099387
ENSMUST00000071537 ENSMUSP00000071467
ENSMUST00000107218 ENSMUSP00000102836
ENSMUST00000107213 ENSMUSP00000102831
ENSMUST00000107212 ENSMUSP00000102830
ENSMUST00000107208 ENSMUSP00000102826
ENSMUST00000147239 ENSMUSP00000122097
ENSMUST00000123558 ENSMUSP00000133619
ENSMUST00000149170
ENSMUST00000127421 ENSMUSP00000121628
ENSMUST00000136185 ENSMUSP00000134500
ENSMUST00000146452
ENSMUST00000127871
ENSMUST00000149019 ENSMUSP00000119900
ENSMUST00000144517
ENSMUST00000148805
ENSMUST00000141170
ENSMUST00000174013
ENSMUST00000172744
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 20 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043130 ubiquitin binding
GO:0051019 mitogen-activated protein kinase binding
Biological Process
GO:0016236 macroautophagy
GO:0030500 regulation of bone mineralization
GO:0032872 regulation of stress-activated MAPK cascade
GO:0045668 negative regulation of osteoblast differentiation
GO:0051259 protein oligomerization
Cellular Component
GO:0000407 pre-autophagosomal structure
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005776 autophagic vacuole
GO:0005829 cytosol
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
GO:0031430 M band
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000188554
View Gene Order
ENSBTAG00000001632
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.784
RefSeq NM_001252220 NM_001252222 NM_001252223 NM_008676 XM_006532430 XM_006532431 XM_006532432 XM_006532433 XM_006532434
OMIM
CCDS CCDS25475 CCDS56810 CCDS56811
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca