InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gfap

Summary

InnateDB Gene

IDBG-212840.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gfap

Gene Name

glial fibrillary acidic protein

Synonyms

AI836096

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020932

Encoded Proteins

IDBP-212842

glial fibrillary acidic protein

IDBP-212844

glial fibrillary acidic protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131095:
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:102887336-102900912

Strand

Reverse strand

Band

Transcripts

ENSMUST00000067444	ENSMUSP00000064691
ENSMUST00000077902	ENSMUSP00000077061
ENSMUST00000127909

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0019900	kinase binding

Biological Process

GO:0009611	response to wounding
GO:0010625	positive regulation of Schwann cell proliferation
GO:0010977	negative regulation of neuron projection development
GO:0014002	astrocyte development
GO:0030198	extracellular matrix organization
GO:0031102	neuron projection regeneration
GO:0045103	intermediate filament-based process
GO:0045109	intermediate filament organization
GO:0051580	regulation of neurotransmitter uptake
GO:0060020	Bergmann glial cell differentiation
GO:0060252	positive regulation of glial cell proliferation
GO:0060291	long-term synaptic potentiation

Cellular Component

GO:0005737	cytoplasm
GO:0005882	intermediate filament
GO:0016020	membrane
GO:0042995	cell projection
GO:0044297	cell body
GO:0097449	astrocyte projection

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000131095

View Gene Order

ENSBTAG00000013534

Not yet available

Pathways

NETPATH

REACTOME

REACT_198574

Nuclear signaling by ERBB4 pathway

REACT_188579

Signaling by ERBB4 pathway

REACT_188257

Signal Transduction pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_116022

Nuclear signaling by ERBB4 pathway

REACT_115596

Signaling by ERBB4 pathway

REACT_111102

Signal Transduction pathway

REACT_216183

Signaling by ERBB4 pathway

REACT_214353

Signal Transduction pathway

REACT_220588

Nuclear signaling by ERBB4 pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.1239

RefSeq

NM_001131020 NM_010277

OMIM

CCDS

CCDS25507 CCDS48950

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas