InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AMN

Summary

InnateDB Gene

IDBG-21311.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AMN

Gene Name

amnionless homolog (mouse)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000166126

Encoded Proteins

IDBP-21313

amnionless homolog (mouse)

IDBP-592964

amnionless homolog (mouse)

IDBP-583181

amnionless homolog (mouse)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:102922656-102933596

Strand

Forward strand

Band

q32.32

Transcripts

ENST00000299155	ENSP00000299155
ENST00000541086
ENST00000558590
ENST00000559442
ENST00000559525	ENSP00000453786
ENST00000559789	ENSP00000452831
ENST00000559507

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006898	receptor-mediated endocytosis
GO:0007275	multicellular organismal development
GO:0007588	excretion
GO:0008104	protein localization
GO:0009235	cobalamin metabolic process
GO:0015889	cobalamin transport
GO:0042157	lipoprotein metabolic process
GO:0043001	Golgi to plasma membrane protein transport
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030139	endocytic vesicle
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome