Version 5.4
Mus musculus Gene: Icam2
Summary
InnateDB Gene IDBG-213473.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Icam2
Gene Name intercellular adhesion molecule 2
Synonyms CD102; Icam-2; Ly-60
Species Mus musculus
Ensembl Gene ENSMUSG00000001029
Encoded Proteins
IDBP-213475
intercellular adhesion molecule 2
IDBP-267991
intercellular adhesion molecule 2
IDBP-536913
intercellular adhesion molecule 2
IDBP-620788
intercellular adhesion molecule 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108622:
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:106377656-106388075
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000001055 ENSMUSP00000001055
ENSMUST00000106813 ENSMUSP00000102426
ENSMUST00000106809
ENSMUST00000141146 ENSMUSP00000118043
ENSMUST00000173795 ENSMUSP00000133315
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
Biological Process
GO:0016337 single organismal cell-cell adhesion
Cellular Component
GO:0001931 uropod
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000108622
View Gene Order
Pathways
NETPATH
REACTOME
REACT_202937
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_230745
Immune System pathway
REACT_206066
Extracellular matrix organization pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_229531
Adaptive Immune System pathway
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_24
TSLP pathway
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_118779
Extracellular matrix organization pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
INOH
PID NCI
integrin2_pathway
Beta2 integrin cell surface interactions
Cross-References
SwissProt P35330
TrEMBL G5E8M9
UniProt Splice Variant
Entrez Gene 15896
UniGene Mm.394
RefSeq NM_010494 XM_006532303 XM_006532304
OMIM
CCDS CCDS25555
HPRD
IMGT
MGI ID MGI:96394
MGI Symbol Icam2
EMBL AK007801 AL604045 BC039128 BC039970 X65490 X65491 X65492 X65493
GenPept AAH39128 AAH39970 BAB25266 CAA46473 CAA46474
RNA Seq Atlas 15896

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca