Mus musculus Gene: Smurf2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-213588.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Smurf2 | ||||||||||||||||||||||
Gene Name | SMAD specific E3 ubiquitin protein ligase 2 | ||||||||||||||||||||||
Synonyms | 2810411E22Rik; AI558114; AI649275 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000018363 | ||||||||||||||||||||||
Encoded Proteins |
SMAD specific E3 ubiquitin protein ligase 2
SMAD specific E3 ubiquitin protein ligase 2
SMAD specific E3 ubiquitin protein ligase 2
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108854:
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 11:106820066-106920715 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | E1 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Downregulation of TGF-beta receptor signaling pathway
Class I MHC mediated antigen processing & presentation pathway
Disease pathway
Signaling by Wnt pathway
Signaling by WNT in cancer pathway
Loss of Function of SMAD4 in Cancer pathway
beta-catenin independent WNT signaling pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Signaling by BMP pathway
TGFBR1 LBD Mutants in Cancer pathway
Immune System pathway
TGF-beta receptor signaling activates SMADs pathway
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
Loss of Function of TGFBR2 in Cancer pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
PCP/CE pathway pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF dependent signaling in response to WNT pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Gene Expression pathway
Adaptive Immune System pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
degradation of AXIN pathway
Asymmetric localization of PCP proteins pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Generic Transcription Pathway pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of SMAD2/3 in Cancer pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
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KEGG |
Ubiquitin mediated proteolysis pathway
TGF-beta signaling pathway pathway
Endocytosis pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
ID pathway
TGF_beta_Receptor pathway
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REACTOME |
Antigen processing: Ubiquitination & Proteasome degradation pathway
Downregulation of TGF-beta receptor signaling pathway
TGF-beta receptor signaling activates SMADs pathway
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
Signaling by BMP pathway
Generic Transcription Pathway pathway
PCP/CE pathway pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
beta-catenin independent WNT signaling pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Signaling by Wnt pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Adaptive Immune System pathway
Immune System pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TCF dependent signaling in response to WNT pathway
Asymmetric localization of PCP proteins pathway
degradation of AXIN pathway
TGFBR1 KD Mutants in Cancer pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Class I MHC mediated antigen processing & presentation pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Gene Expression pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
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KEGG |
TGF-beta signaling pathway pathway
Ubiquitin mediated proteolysis pathway
Endocytosis pathway
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INOH |
TGF-beta signaling pathway
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PID NCI |
BMP receptor signaling
TGF-beta receptor signaling
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.484789 | ||||||||||||||||||||||
RefSeq | NM_025481 XM_006533935 XM_006533936 XM_006533938 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS25564 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||