Version 5.4
Mus musculus Gene: Bptf
Summary
InnateDB Gene IDBG-213646.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bptf
Gene Name bromodomain PHD finger transcription factor
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000040481
Encoded Proteins
IDBP-213664
bromodomain PHD finger transcription factor
IDBP-268094
bromodomain PHD finger transcription factor
IDBP-268096
bromodomain PHD finger transcription factor
IDBP-537136
bromodomain PHD finger transcription factor
IDBP-534494
bromodomain PHD finger transcription factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171634:
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer\'s disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:107033081-107132127
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000057892 ENSMUSP00000052303
ENSMUST00000106763 ENSMUSP00000102374
ENSMUST00000106762 ENSMUSP00000102373
ENSMUST00000147816
ENSMUST00000138443
ENSMUST00000133317 ENSMUSP00000118875
ENSMUST00000149486 ENSMUSP00000122575
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008094 DNA-dependent ATPase activity
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001892 embryonic placenta development
GO:0006200 ATP catabolic process
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007010 cytoskeleton organization
GO:0007420 brain development
GO:0007492 endoderm development
GO:0009952 anterior/posterior pattern specification
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
GO:0016589 NURF complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171634
View Gene Order
ENSBTAG00000014598
Not yet available
Cross-References
SwissProt
TrEMBL E9Q6A7 Q6P9L3 Q8C473
UniProt Splice Variant
Entrez Gene 207165
UniGene Mm.343986 Mm.412605
RefSeq NM_176850
OMIM
CCDS CCDS48964
HPRD
IMGT
MGI ID MGI:2444008
MGI Symbol Bptf
EMBL AK082852 AL596116 BC060715
GenPept AAH60715 BAC38653
RNA Seq Atlas 207165

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca