Version 5.4
Mus musculus Gene: Phactr3
Summary
InnateDB Gene IDBG-213655.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Phactr3
Gene Name phosphatase and actin regulator 3
Synonyms 1500003N10Rik; 4930415A02Rik; H17739; mKIAA4224; Scapin1; Scapinin
Species Mus musculus
Ensembl Gene ENSMUSG00000027525
Encoded Proteins
IDBP-213657
phosphatase and actin regulator 3
IDBP-213661
phosphatase and actin regulator 3
IDBP-263515
phosphatase and actin regulator 3
IDBP-263517
phosphatase and actin regulator 3
IDBP-263519
phosphatase and actin regulator 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087495:
The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:178118975-178338492
Strand Forward strand
Band H4
Transcripts
ENSMUST00000103066 ENSMUSP00000099355
ENSMUST00000103065 ENSMUSP00000099354
ENSMUST00000108917 ENSMUSP00000104545
ENSMUST00000108916 ENSMUSP00000104544
ENSMUST00000108915 ENSMUSP00000104543
ENSMUST00000141272
ENSMUST00000133267
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004864 protein phosphatase inhibitor activity
Biological Process
GO:0008150 biological_process
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005634 nucleus
GO:0016363 nuclear matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000087495
View Gene Order
ENSBTAG00000015080
Not yet available
Cross-References
SwissProt Q8BYK5
TrEMBL A2AHM4 Q5DTG6 Q6KCA9
UniProt Splice Variant
Entrez Gene 74189
UniGene Mm.396744 Mm.44413
RefSeq NM_001007154 NM_001177789 NM_001177790 NM_001177791 NM_028806 XM_006500730
OMIM
CCDS CCDS17158 CCDS17159 CCDS50837 CCDS50838 CCDS50839
HPRD
IMGT
MGI ID MGI:1921439
MGI Symbol Phactr3
EMBL AJ632220 AJ632221 AJ632222 AJ632223 AK005136 AK032242 AK038449 AK039213 AK220554 AL731783 AL772217 AY501387 BC058621 BC059869
GenPept AAH58621 AAH59869 AAS86433 BAB23834 BAC27776 BAC30003 BAC30278 BAD90539 CAG14990 CAG14991 CAG14992 CAG14993
RNA Seq Atlas 74189

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca