Version 5.4
Homo sapiens Gene: IFNGR2
Summary
InnateDB Gene IDBG-2140.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFNGR2
Gene Name interferon gamma receptor 2 (interferon gamma transducer 1)
Synonyms AF-1; IFGR2; IFNGT1; IMD28
Species Homo sapiens
Ensembl Gene ENSG00000159128
Encoded Proteins
IDBP-2144
interferon gamma receptor 2 (interferon gamma transducer 1)
IDBP-2146
interferon gamma receptor 2 (interferon gamma transducer 1)
IDBP-292636
interferon gamma receptor 2 (interferon gamma transducer 1)
IDBP-362830
interferon gamma receptor 2 (interferon gamma transducer 1)
IDBP-362846
interferon gamma receptor 2 (interferon gamma transducer 1)
IDBP-597916
interferon gamma receptor 2 (interferon gamma transducer 1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 9001223
IFNGR2 associates with JAK2 and this is required for IFN-gamma signalling.
PMID 16467883
IFNRG2 complex is activated by STAT1, leading to the transcription of a significant portion of IFN-gamma induced genes, many of which are responsible for the induction of an apoptotic state in response to IFN-gamma.
Entrez Gene
Summary This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:33402896-33479348
Strand Forward strand
Band q22.11
Transcripts
ENST00000290219 ENSP00000290219
ENST00000381995 ENSP00000371425
ENST00000405436 ENSP00000385044
ENST00000439213 ENSP00000407541
ENST00000421802 ENSP00000402629
ENST00000545369 ENSP00000442735
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004906 interferon-gamma receptor activity
GO:0005515 protein binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0009615 response to virus
GO:0019221 cytokine-mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000022965
View Gene Order
Pathways
NETPATH
REACTOME
REACT_24980
Regulation of IFNG signaling pathway
REACT_25078
Interferon gamma signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05140
Leishmaniasis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
hsa05145
Toxoplasmosis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IFN gamma signaling pathway
PID NCI
Cross-References
SwissProt P38484
TrEMBL A1Z2N6 A8K881 B5MCZ0
UniProt Splice Variant
Entrez Gene 3460
UniGene Hs.620349 Hs.634632 Hs.644872
RefSeq NM_005534 XM_005260969
HUGO HGNC:5440
OMIM 147569
CCDS CCDS33544
HPRD 00956
IMGT
EMBL AK292246 AK314005 AP000299 AP000300 AP000301 AP000302 AY644470 BC003624 CH471079 EF173886 U05875 U05877 U68755
GenPept AAA16955 AAA16956 AAC52066 AAH03624 AAT45458 ABM53159 BAF84935 BAG36717 EAX09834 EAX09835
RNA Seq Atlas 3460

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca