InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ptk6

Summary

InnateDB Gene

IDBG-214016.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptk6

Gene Name

PTK6 protein tyrosine kinase 6

Synonyms

BRK; Sik; tks; Tksk

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038751

Encoded Proteins

IDBP-214018

PTK6 protein tyrosine kinase 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101213:
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:181193721-181202789

Strand

Reverse strand

Band

Transcripts

ENSMUST00000016511

ENSMUSP00000016511

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0010976	positive regulation of neuron projection development
GO:0016477	cell migration
GO:0042503	tyrosine phosphorylation of Stat3 protein
GO:0042506	tyrosine phosphorylation of Stat5 protein
GO:0045926	negative regulation of growth
GO:0046777	protein autophosphorylation
GO:0060575	intestinal epithelial cell differentiation
GO:0061099	negative regulation of protein tyrosine kinase activity
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000101213

View Gene Order

ENSBTAG00000044091

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q64434

TrEMBL

Q05AA8

UniProt Splice Variant

Entrez Gene

20459

UniGene

Mm.4497

RefSeq

NM_009184 XM_006500585

OMIM

CCDS

CCDS17203

HPRD

IMGT

MGI ID

MGI:99683

MGI Symbol

Ptk6

EMBL

AF016545 BC125342 BC125344 CH466626 U16805

GenPept

AAA67929 AAB94550 AAI25343 AAI25345 EDL07394

RNA Seq Atlas

20459