InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sox18

Summary

InnateDB Gene

IDBG-214180.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sox18

Gene Name

SRY-box containing gene 18

Synonyms

AI385749; Ra; Ragl

Species

Mus musculus

Ensembl Gene

ENSMUSG00000046470

Encoded Proteins

IDBP-214182

SRY-box containing gene 18

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000203883:
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:181669836-181671640

Strand

Reverse strand

Band

Transcripts

ENSMUST00000054491

ENSMUSP00000062759

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001568	blood vessel development
GO:0001570	vasculogenesis
GO:0001701	in utero embryonic development
GO:0001942	hair follicle development
GO:0001944	vasculature development
GO:0001945	lymph vessel development
GO:0001946	lymphangiogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0007507	heart development
GO:0022405	hair cycle process
GO:0035050	embryonic heart tube development
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0043534	blood vessel endothelial cell migration
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048469	cell maturation
GO:0048866	stem cell fate specification
GO:0060214	endocardium formation
GO:0060836	lymphatic endothelial cell differentiation
GO:0060956	endocardial cell differentiation
GO:0061028	establishment of endothelial barrier
GO:0072091	regulation of stem cell proliferation

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0044798	nuclear transcription factor complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000203883

View Gene Order

ENSBTAG00000011662

Not yet available

Cross-References

SwissProt

P43680

TrEMBL

UniProt Splice Variant

Entrez Gene

20672

UniGene

Mm.264904

RefSeq

NM_009236

OMIM

CCDS

CCDS17218

HPRD

IMGT

MGI ID

MGI:103559

MGI Symbol

Sox18

EMBL

AF288518 BC006612 L29086 L35032

GenPept

AAA56844 AAB18615 AAG48578 AAH06612

RNA Seq Atlas

20672