Version 5.4
Mus musculus Gene: Polr3k
Summary
InnateDB Gene IDBG-214254.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Polr3k
Gene Name polymerase (RNA) III (DNA directed) polypeptide K
Synonyms 12.3kDa; 1500004O14Rik; AI196849; AU014893; C11; RPC10; RPC11
Species Mus musculus
Ensembl Gene ENSMUSG00000038628
Encoded Proteins
IDBP-214256
polymerase (RNA) III (DNA directed) polypeptide K
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161980:
This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:181864337-181870830
Strand Forward strand
Band H4
Transcripts
ENSMUST00000039551 ENSMUSP00000044582
ENSMUST00000153214
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001056 RNA polymerase III activity
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006386 termination of RNA polymerase III transcription
GO:0045087 innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0005666 DNA-directed RNA polymerase III complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000161980
View Gene Order
ENSBTAG00000019803
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_244415
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_233104
RNA Polymerase III Transcription Initiation pathway
REACT_250309
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
REACT_230745
Immune System pathway
REACT_251592
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
REACT_261233
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_218897
Cytosolic sensors of pathogen-associated DNA pathway
REACT_233572
Gene Expression pathway
REACT_221403
RNA Polymerase III Transcription Termination pathway
REACT_237241
RNA Polymerase III Transcription pathway
REACT_240508
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
REACT_205207
RNA Polymerase III Chain Elongation pathway
KEGG
mmu00240
Pyrimidine metabolism pathway
mmu03020
RNA polymerase pathway
mmu00230
Purine metabolism pathway
mmu04623
Cytosolic DNA-sensing pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22339
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_63
RNA Polymerase III Transcription Termination pathway
REACT_756
RNA Polymerase III Chain Elongation pathway
REACT_571
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
REACT_1036
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
REACT_347
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
REACT_281
RNA Polymerase III Transcription Initiation pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_1371
RNA Polymerase III Transcription pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_71
Gene Expression pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
hsa03020
RNA polymerase pathway
hsa04623
Cytosolic DNA-sensing pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q9CQZ7
TrEMBL Q3TSW1
UniProt Splice Variant
Entrez Gene 67005
UniGene
RefSeq NM_025901
OMIM
CCDS CCDS17225
HPRD
IMGT
MGI ID MGI:1914255
MGI Symbol Polr3k
EMBL AK005152 AK010875 AK021353 AK031110 AK161764
GenPept BAB23846 BAB27239 BAB32384 BAC27257 BAE36564
RNA Seq Atlas 67005

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca