Version 5.4
Mus musculus Gene: Llgl2
Summary
InnateDB Gene IDBG-214360.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Llgl2
Gene Name lethal giant larvae homolog 2 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020782
Encoded Proteins
IDBP-214362
lethal giant larvae homolog 2 (Drosophila)
IDBP-542049
lethal giant larvae homolog 2 (Drosophila)
IDBP-542055
lethal giant larvae homolog 2 (Drosophila)
IDBP-542790
lethal giant larvae homolog 2 (Drosophila)
IDBP-542789
lethal giant larvae homolog 2 (Drosophila)
IDBP-622403
lethal giant larvae homolog 2 (Drosophila)
IDBP-622406
lethal giant larvae homolog 2 (Drosophila)
IDBP-719037
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073350:
The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein\'s ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:115824049-115855780
Strand Forward strand
Band E2
Transcripts
ENSMUST00000103032 ENSMUSP00000099321
ENSMUST00000133250 ENSMUSP00000118344
ENSMUST00000155878 ENSMUSP00000117649
ENSMUST00000137900 ENSMUSP00000119675
ENSMUST00000137951
ENSMUST00000130518
ENSMUST00000128826 ENSMUSP00000118304
ENSMUST00000147878
ENSMUST00000132999
ENSMUST00000172552 ENSMUSP00000133803
ENSMUST00000173289 ENSMUSP00000133790
ENSMUST00000177736 ENSMUSP00000136054
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030165 PDZ domain binding
Biological Process
GO:0006887 exocytosis
GO:0007049 cell cycle
GO:0032878 regulation of establishment or maintenance of cell polarity
GO:0051301 cell division
Cellular Component
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000073350
View Gene Order
ENSBTAG00000020067
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04530
Tight junction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.290450
RefSeq NM_001252532 NM_145438 XM_006533083 XM_006533084
OMIM
CCDS CCDS25649 CCDS56820
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca