InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Acox1

Summary

InnateDB Gene

IDBG-214419.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acox1

Gene Name

acyl-Coenzyme A oxidase 1, palmitoyl

Synonyms

Acox; AOX; D130055E20Rik; Paox

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020777

Encoded Proteins

IDBP-214421

acyl-Coenzyme A oxidase 1, palmitoyl

IDBP-214425

acyl-Coenzyme A oxidase 1, palmitoyl

IDBP-537847

acyl-Coenzyme A oxidase 1, palmitoyl

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the acyl-coenzyme A oxidase family. The encoded protein is localized to peroxisomes and is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-coenzyme A to 2-trans-enoyl-coenzyme A. Disruption of this gene results in microvesicular steatohepatitis, spontaneous peroxisome proliferation, and the eventual development of hepatocellular carcinomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:116171888-116199045

Strand

Reverse strand

Band

Transcripts

ENSMUST00000066587	ENSMUSP00000063325
ENSMUST00000072948	ENSMUSP00000072717
ENSMUST00000148601	ENSMUSP00000122185
ENSMUST00000130229
ENSMUST00000150549
ENSMUST00000128793
ENSMUST00000124684

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003995	acyl-CoA dehydrogenase activity
GO:0003997	acyl-CoA oxidase activity
GO:0005102	receptor binding
GO:0005504	fatty acid binding
GO:0016401	palmitoyl-CoA oxidase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0030165	PDZ domain binding
GO:0047485	protein N-terminus binding
GO:0050660	flavin adenine dinucleotide binding
GO:0071949	FAD binding

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0006091	generation of precursor metabolites and energy
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006693	prostaglandin metabolic process
GO:0007283	spermatogenesis
GO:0008152	metabolic process
GO:0016559	peroxisome fission
GO:0019395	fatty acid oxidation
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase
GO:0055088	lipid homeostasis
GO:0055114	oxidation-reduction process
GO:2000189	positive regulation of cholesterol homeostasis