Version 5.4
Mus musculus Gene: Tmc8
Summary
InnateDB Gene IDBG-214578.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmc8
Gene Name transmembrane channel-like gene family 8
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000050106
Encoded Proteins
IDBP-214580
transmembrane channel-like gene family 8
IDBP-268987
transmembrane channel-like gene family 8
IDBP-401784
transmembrane channel-like gene family 8
IDBP-401785
transmembrane channel-like gene family 8
IDBP-532490
transmembrane channel-like gene family 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167895:
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:117782076-117793110
Strand Forward strand
Band E2
Transcripts
ENSMUST00000050874 ENSMUSP00000051878
ENSMUST00000106334 ENSMUSP00000101941
ENSMUST00000117781 ENSMUSP00000113570
ENSMUST00000119455 ENSMUSP00000113628
ENSMUST00000127080 ENSMUSP00000115270
ENSMUST00000156458
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006811 ion transport
GO:0032091 negative regulation of protein binding
GO:0032460 negative regulation of protein oligomerization
GO:0055069 zinc ion homeostasis
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167895
View Gene Order
ENSBTAG00000019067
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.116675 Mm.488728
RefSeq NM_001195088 NM_001195089 NM_001195090 NM_181856 XM_006533123 XM_006533124 XM_006533125 XM_006533127
OMIM
CCDS CCDS25689 CCDS56824 CCDS56825
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca