InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Birc5

Summary

InnateDB Gene

IDBG-214593.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Birc5

Gene Name

baculoviral IAP repeat-containing 5

Synonyms

AAC-11; Api4; survivin40; TIAP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000017716

Encoded Proteins

IDBP-214595

baculoviral IAP repeat-containing 5

IDBP-214597

baculoviral IAP repeat-containing 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20406824

[Homo sapiens] BIRC5 is cleaved by GZMM (granzyme M) and this triggers degradation of the BIRC5-XIAP complex to free caspase activity, leading to cytolysis of target cells.

Entrez Gene

Summary

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene\'s expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:117849251-117855743

Strand

Forward strand

Band

Transcripts

ENSMUST00000081387	ENSMUSP00000079124
ENSMUST00000093906	ENSMUSP00000091433

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008270	zinc ion binding
GO:0015631	tubulin binding
GO:0042803	protein homodimerization activity
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0048037	cofactor binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000226	microtubule cytoskeleton organization
GO:0000910	cytokinesis
GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007346	regulation of mitotic cell cycle
GO:0031503	protein complex localization
GO:0031536	positive regulation of exit from mitosis
GO:0031577	spindle checkpoint
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045931	positive regulation of mitotic cell cycle
GO:0051301	cell division
GO:0051303	establishment of chromosome localization
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061469	regulation of type B pancreatic cell proliferation

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005814	centriole
GO:0005829	cytosol
GO:0005876	spindle microtubule
GO:0005881	cytoplasmic microtubule
GO:0030496	midbody
GO:0031021	interphase microtubule organizing center
GO:0032133	chromosome passenger complex