InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rptor

Summary

InnateDB Gene

IDBG-214724.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rptor

Gene Name

regulatory associated protein of MTOR, complex 1

Synonyms

4932417H02Rik; mKIAA1303; Rap; Raptor

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025583

Encoded Proteins

IDBP-214726

regulatory associated protein of MTOR, complex 1

IDBP-532427

regulatory associated protein of MTOR, complex 1

IDBP-534692

regulatory associated protein of MTOR, complex 1

IDBP-542417

regulatory associated protein of MTOR, complex 1

IDBP-534102

regulatory associated protein of MTOR, complex 1

IDBP-535043

regulatory associated protein of MTOR, complex 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141564:
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:119602905-119899576

Strand

Forward strand

Band

Transcripts

ENSMUST00000026671	ENSMUSP00000026671
ENSMUST00000125583
ENSMUST00000130049
ENSMUST00000147772
ENSMUST00000147781	ENSMUSP00000124366
ENSMUST00000127899
ENSMUST00000139728	ENSMUSP00000124886
ENSMUST00000126802
ENSMUST00000124401	ENSMUSP00000125503
ENSMUST00000136662	ENSMUSP00000125293
ENSMUST00000148860
ENSMUST00000131217	ENSMUSP00000125667

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	71 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001030	RNA polymerase III type 1 promoter DNA binding
GO:0001031	RNA polymerase III type 2 promoter DNA binding
GO:0001032	RNA polymerase III type 3 promoter DNA binding
GO:0001156	TFIIIC-class transcription factor binding
GO:0005488	binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0008361	regulation of cell size
GO:0016049	cell growth
GO:0031669	cellular response to nutrient levels
GO:0031929	TOR signaling
GO:0032008	positive regulation of TOR signaling
GO:0042325	regulation of phosphorylation
GO:0045945	positive regulation of transcription from RNA polymerase III promoter
GO:0071230	cellular response to amino acid stimulus
GO:0071902	positive regulation of protein serine/threonine kinase activity