InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pde6g

Summary

InnateDB Gene

IDBG-214806.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde6g

Gene Name

phosphodiesterase 6G, cGMP-specific, rod, gamma

Synonyms

p3AT; Pdeg

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025386

Encoded Proteins

IDBP-214808

phosphodiesterase 6G, cGMP-specific, rod, gamma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185527:
This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:120447605-120453500

Strand

Reverse strand

Band

Transcripts

ENSMUST00000026452	ENSMUSP00000026452
ENSMUST00000141795
ENSMUST00000155421

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0030507	spectrin binding
GO:0030553	cGMP binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0007601	visual perception
GO:0008152	metabolic process
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
GO:0050896	response to stimulus