Version 5.4
Homo sapiens Gene: UGT2B15
Summary
InnateDB Gene IDBG-21500.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UGT2B15
Gene Name UDP glucuronosyltransferase 2 family, polypeptide B15
Synonyms HLUG4; UDPGT 2B8; UDPGT2B15; UDPGTH3; UGT2B8
Species Homo sapiens
Ensembl Gene ENSG00000196620
Encoded Proteins
IDBP-21502
UDP glucuronosyltransferase 2 family, polypeptide B15
IDBP-808665
UDP glucuronosyltransferase 2 family, polypeptide B15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the UDP-glycosyltransferase (UDPGT) family. The UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein displays activity towards several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:68537413-68670628
Strand Reverse strand
Band q13.2
Transcripts
ENST00000338206 ENSP00000341045
ENST00000616841 ENSP00000482004
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 0
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015020 glucuronosyltransferase activity
GO:0016758 transferase activity, transferring hexosyl groups
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
GO:0008202 steroid metabolic process
GO:0030259 lipid glycosylation
GO:0052695 cellular glucuronidation
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_6784
Glucuronidation pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00830
Retinol metabolism pathway
hsa00040
Pentose and glucuronate interconversions pathway
hsa00500
Starch and sucrose metabolism pathway
hsa00140
Steroid hormone biosynthesis pathway
hsa00053
Ascorbate and aldarate metabolism pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa00860
Porphyrin and chlorophyll metabolism pathway
hsa00982
Drug metabolism pathway
hsa00983
Drug metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001076
HUGO
OMIM
CCDS CCDS3524
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca