InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PPM1F

Summary

InnateDB Gene

IDBG-2163.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPM1F

Gene Name

protein phosphatase, Mg2+/Mn2+ dependent, 1F

Synonyms

CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2

Species

Homo sapiens

Ensembl Gene

ENSG00000100034

Encoded Proteins

IDBP-2165

protein phosphatase, Mg2+/Mn2+ dependent, 1F

IDBP-235262

protein phosphatase, Mg2+/Mn2+ dependent, 1F

IDBP-292712

protein phosphatase, Mg2+/Mn2+ dependent, 1F

IDBP-365372

protein phosphatase, Mg2+/Mn2+ dependent, 1F

IDBP-365375

protein phosphatase, Mg2+/Mn2+ dependent, 1F

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:21919420-21952837

Strand

Reverse strand

Band

q11.22

Transcripts

ENST00000263212	ENSP00000263212
ENST00000397495	ENSP00000380632
ENST00000407142	ENSP00000384930
ENST00000445205	ENSP00000392372
ENST00000424647	ENSP00000388350
ENST00000496143
ENST00000484588
ENST00000486259
ENST00000497072
ENST00000623652

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0033192	calmodulin-dependent protein phosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0006470	protein dephosphorylation
GO:0010628	positive regulation of gene expression
GO:0010634	positive regulation of epithelial cell migration
GO:0010811	positive regulation of cell-substrate adhesion
GO:0016576	histone dephosphorylation
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0035690	cellular response to drug
GO:0035970	peptidyl-threonine dephosphorylation
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045927	positive regulation of growth
GO:0050921	positive regulation of chemotaxis
GO:0051496	positive regulation of stress fiber assembly
GO:0051894	positive regulation of focal adhesion assembly
GO:0097193	intrinsic apoptotic signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026181

View Gene Order

ENSBTAG00000006938

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.623512 Hs.738863

RefSeq

NM_014634

HUGO

OMIM

CCDS

CCDS13796

HPRD

10163

IMGT

EMBL

GenPept

RNA Seq Atlas