InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TH

Summary

InnateDB Gene

IDBG-21705.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

tyrosine hydroxylase

Synonyms

DYT14; DYT5b; TYH

Species

Homo sapiens

Ensembl Gene

ENSG00000180176

Encoded Proteins

IDBP-21709

tyrosine hydroxylase

IDBP-21711

tyrosine hydroxylase

IDBP-21713

tyrosine hydroxylase

IDBP-21715

tyrosine hydroxylase

IDBP-21717

tyrosine hydroxylase

IDBP-21719

tyrosine hydroxylase

IDBP-361886

tyrosine hydroxylase

IDBP-361889

tyrosine hydroxylase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:2163929-2171877

Strand

Reverse strand

Band

p15.5

Transcripts

ENST00000381178	ENSP00000370571
ENST00000381175	ENSP00000370567
ENST00000352909	ENSP00000325951
ENST00000333684	ENSP00000328814
ENST00000324155	ENSP00000325831
ENST00000381168	ENSP00000370560
ENST00000412076	ENSP00000403546
ENST00000416223	ENSP00000403440
ENST00000479437
ENST00000461172
ENST00000469226

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0004511	tyrosine 3-monooxygenase activity
GO:0005515	protein binding
GO:0008198	ferrous iron binding
GO:0008199	ferric iron binding
GO:0016597	amino acid binding
GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0019825	oxygen binding
GO:0019904	protein domain specific binding
GO:0034617	tetrahydrobiopterin binding
GO:0035240	dopamine binding

Biological Process

GO:0001666	response to hypoxia
GO:0001963	synaptic transmission, dopaminergic
GO:0001975	response to amphetamine
GO:0003007	heart morphogenesis
GO:0006585	dopamine biosynthetic process from tyrosine
GO:0006631	fatty acid metabolic process
GO:0006665	sphingolipid metabolic process
GO:0007507	heart development
GO:0007601	visual perception
GO:0007605	sensory perception of sound
GO:0007612	learning
GO:0007613	memory
GO:0007617	mating behavior
GO:0007626	locomotory behavior
GO:0008016	regulation of heart contraction
GO:0009414	response to water deprivation
GO:0009416	response to light stimulus
GO:0009635	response to herbicide
GO:0009651	response to salt stress
GO:0009653	anatomical structure morphogenesis
GO:0009887	organ morphogenesis
GO:0010038	response to metal ion
GO:0010043	response to zinc ion
GO:0010259	multicellular organismal aging
GO:0014070	response to organic cyclic compound
GO:0014823	response to activity
GO:0015842	synaptic vesicle amine transport
GO:0016137	glycoside metabolic process
GO:0017085	response to insecticide
GO:0018963	phthalate metabolic process
GO:0021987	cerebral cortex development
GO:0031667	response to nutrient levels
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0033076	isoquinoline alkaloid metabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0035094	response to nicotine
GO:0035176	social behavior
GO:0035690	cellular response to drug
GO:0035902	response to immobilization stress
GO:0042136	neurotransmitter biosynthetic process
GO:0042214	terpene metabolic process
GO:0042416	dopamine biosynthetic process
GO:0042418	epinephrine biosynthetic process
GO:0042421	norepinephrine biosynthetic process
GO:0042423	catecholamine biosynthetic process
GO:0042462	eye photoreceptor cell development
GO:0042493	response to drug
GO:0042745	circadian sleep/wake cycle
GO:0042755	eating behavior
GO:0043434	response to peptide hormone
GO:0043473	pigmentation
GO:0044281	small molecule metabolic process
GO:0045471	response to ethanol
GO:0045472	response to ether
GO:0046684	response to pyrethroid
GO:0048545	response to steroid hormone
GO:0048596	embryonic camera-type eye morphogenesis
GO:0050890	cognition
GO:0051412	response to corticosterone
GO:0051602	response to electrical stimulus
GO:0052314	phytoalexin metabolic process
GO:0055114	oxidation-reduction process
GO:0070848	response to growth factor
GO:0071287	cellular response to manganese ion
GO:0071312	cellular response to alkaloid
GO:0071316	cellular response to nicotine
GO:0071333	cellular response to glucose stimulus
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005790	smooth endoplasmic reticulum
GO:0005829	cytosol
GO:0008021	synaptic vesicle
GO:0009898	cytoplasmic side of plasma membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0033162	melanosome membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043204	perikaryon