InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL4R

Summary

InnateDB Gene

IDBG-21808.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL4R

Gene Name

interleukin 4 receptor

Synonyms

CD124; IL-4RA; IL4RA

Species

Homo sapiens

Ensembl Gene

ENSG00000077238

Encoded Proteins

IDBP-21810

interleukin 4 receptor

IDBP-238894

interleukin 4 receptor

IDBP-595849

interleukin 4 receptor

IDBP-750800

IDBP-748940

IDBP-745083

IDBP-751040

IDBP-752960

IDBP-752873

IDBP-746443

IDBP-749614

IDBP-753244

IDBP-751458

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 8609418

IL4R is utilized by IL13 to induce phosphorylation and activation of JAK2 in human colon carcinoma cell lines.

PMID 21825018

The IL4R signalling pathway contributes to the heightened susceptibility of mice co-infected with Mycobacterium tuberculosis and the intestinal helminth, Nippostrongylus brasiliensis. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 21825018

[Mus musculus] The Il4ra signalling pathway contributes to the heightened susceptibility of mice co-infected with Mycobacterium tuberculosis and the intestinal helminth, Nippostrongylus brasiliensis

Entrez Gene

Summary

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:27313668-27364778

Strand

Forward strand

Band

p12.1

Transcripts

ENST00000170630	ENSP00000170630
ENST00000395762	ENSP00000379111
ENST00000543915	ENSP00000441667
ENST00000561742	ENSP00000454725
ENST00000565915
ENST00000566117	ENSP00000455632
ENST00000563787
ENST00000568746	ENSP00000455714
ENST00000562968	ENSP00000456669
ENST00000565696
ENST00000565352	ENSP00000461268
ENST00000563002	ENSP00000456930
ENST00000563926	ENSP00000454684
ENST00000566318	ENSP00000456248
ENST00000563886
ENST00000562142	ENSP00000457131
ENST00000561946
ENST00000565179	ENSP00000461607

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	37 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0004913	interleukin-4 receptor activity
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0043560	insulin receptor substrate binding

Biological Process

GO:0002532	production of molecular mediator involved in inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0019221	cytokine-mediated signaling pathway
GO:0030728	ovulation
GO:0035556	intracellular signal transduction
GO:0035771	interleukin-4-mediated signaling pathway
GO:0042127	regulation of cell proliferation
GO:0042832	defense response to protozoan
GO:0043032	positive regulation of macrophage activation
GO:0043627	response to estrogen
GO:0045087	innate immune response (InnateDB)
GO:0045626	negative regulation of T-helper 1 cell differentiation
GO:0045630	positive regulation of T-helper 2 cell differentiation
GO:0090197	positive regulation of chemokine secretion

Cellular Component

GO:0005615	extracellular space
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030748

View Gene Order

ENSBTAG00000001602

Not yet available

Pathways

NETPATH

NetPath_16

IL4 pathway

REACTOME

KEGG

hsa04640

Hematopoietic cell lineage pathway

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04630

Jak-STAT signaling pathway pathway

INOH

INOH website

IL-4 signaling pathway

INOH website

JAK STAT pathway and regulation pathway

INOH website

IL-13 signaling pathway

PID NCI

p73pathway

p73 transcription factor network

il4_2pathway

IL4-mediated signaling events

Cross-References

SwissProt

P24394

TrEMBL

A1Z2K8 H3BTD9 J9JII2

UniProt Splice Variant

Entrez Gene

3566

UniGene

Hs.513457 Hs.742121

RefSeq

NM_001257406 NM_001257997 XM_005255305 XM_005255308 XM_006721043 NM_000418 NM_001257407

HUGO

HGNC:6015

OMIM

147781

CCDS

CCDS10629 CCDS58441

HPRD

00990

IMGT

EMBL

AC004525 AC106739 AF421855 AJ293647 AJ293648 AJ293649 AJ293650 AJ293651 AJ293652 AJ293653 AJ293654 AK303255 BC151131 EF173858 X52425

GenPept

AAC23495 AAI51132 AAL12163 ABM53131 BAG64338 CAA36672 CAC20445 CAC20446 CAC20447 CAC20448 CAC20449 CAC20450 CAC20451 CAC20452

RNA Seq Atlas

3566