Version 5.4
Homo sapiens Gene: RNF138
Summary
InnateDB Gene IDBG-2188.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF138
Gene Name ring finger protein 138, E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134758
Encoded Proteins
IDBP-2190
ring finger protein 138
IDBP-2192
ring finger protein 138
IDBP-726737
IDBP-727126
IDBP-725903
IDBP-726810
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:32091855-32131561
Strand Forward strand
Band q12.1
Transcripts
ENST00000261593 ENSP00000261593
ENST00000257190 ENSP00000257190
ENST00000585103
ENST00000578914 ENSP00000462165
ENST00000580519
ENST00000583733
ENST00000580499 ENSP00000463153
ENST00000578107 ENSP00000462498
ENST00000577999 ENSP00000463659
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0019901 protein kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0016055 Wnt signaling pathway
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024317
View Gene Order
ENSBTAG00000020160
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL J3KSI2
UniProt Splice Variant
Entrez Gene 51444
UniGene Hs.302408 Hs.661501
RefSeq NM_001191324 NM_016271 NM_198128 XM_005258286
HUGO HGNC:17765
OMIM
CCDS CCDS11903 CCDS11904
HPRD 11508
IMGT
EMBL AC011825
GenPept
RNA Seq Atlas 51444

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca