Homo sapiens Gene: MRPL15
Summary
InnateDB Gene IDBG-21946.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPL15
Gene Name mitochondrial ribosomal protein L15
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137547
Encoded Proteins
mitochondrial ribosomal protein L15
mitochondrial ribosomal protein L15
mitochondrial ribosomal protein L15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:54135210-54147901
Strand Forward strand
Band q11.23
Transcripts
ENST00000260102 ENSP00000260102
ENST00000519831 ENSP00000428581
ENST00000522521 ENSP00000429252
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
Experimentally validated
Total 40 [view]
Protein-Protein 37 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005739 mitochondrion
GO:0015934 large ribosomal subunit
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
KEGG
Ribosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E5RIZ4
UniProt Splice Variant
Entrez Gene 29088
UniGene Hs.18349
RefSeq NM_014175
HUGO HGNC:14054
OMIM 611828
CCDS CCDS6158
HPRD 14742
IMGT
EMBL AC060764
GenPept
RNA Seq Atlas 29088