Version 5.4
Homo sapiens Gene: PPP1R13B
Summary
InnateDB Gene IDBG-22173.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1R13B
Gene Name protein phosphatase 1, regulatory subunit 13B
Synonyms ASPP1; p53BP2-like; p85
Species Homo sapiens
Ensembl Gene ENSG00000088808
Encoded Proteins
IDBP-22175
protein phosphatase 1, regulatory subunit 13B
IDBP-592558
protein phosphatase 1, regulatory subunit 13B
IDBP-594195
protein phosphatase 1, regulatory subunit 13B
IDBP-591664
protein phosphatase 1, regulatory subunit 13B
IDBP-600844
protein phosphatase 1, regulatory subunit 13B
IDBP-589348
protein phosphatase 1, regulatory subunit 13B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:103733752-103847590
Strand Reverse strand
Band q32.33
Transcripts
ENST00000202556 ENSP00000202556
ENST00000557587 ENSP00000451433
ENST00000555825
ENST00000556597 ENSP00000451739
ENST00000557082 ENSP00000451396
ENST00000555391
ENST00000556334
ENST00000554432
ENST00000556325
ENST00000555991
ENST00000557744
ENST00000555183
ENST00000555708
ENST00000554106
ENST00000555734 ENSP00000452376
ENST00000554136
ENST00000553739 ENSP00000450734
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 28 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008134 transcription factor binding
Biological Process
GO:0006915 apoptotic process
GO:0045786 negative regulation of cell cycle
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021285
View Gene Order
ENSBTAG00000003559
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.709297 Hs.740057
RefSeq NM_015316 XM_005267484 XM_005267485 XM_005267487
HUGO
OMIM
CCDS CCDS41997
HPRD 07345
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca