InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: APEX1

Summary

InnateDB Gene

IDBG-2246.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APEX1

Gene Name

APEX nuclease (multifunctional DNA repair enzyme) 1

Synonyms

APE; APE1; APEN; APEX; APX; HAP1; REF1

Species

Homo sapiens

Ensembl Gene

ENSG00000100823

Encoded Proteins

IDBP-2248

APEX nuclease (multifunctional DNA repair enzyme) 1

IDBP-234002

APEX nuclease (multifunctional DNA repair enzyme) 1

IDBP-360669

APEX nuclease (multifunctional DNA repair enzyme) 1

IDBP-595520

APEX nuclease (multifunctional DNA repair enzyme) 1

IDBP-585571

APEX nuclease (multifunctional DNA repair enzyme) 1

IDBP-593750

APEX nuclease (multifunctional DNA repair enzyme) 1

IDBP-601929

APEX nuclease (multifunctional DNA repair enzyme) 1

IDBP-585473

APEX nuclease (multifunctional DNA repair enzyme) 1

IDBP-591558

APEX nuclease (multifunctional DNA repair enzyme) 1

IDBP-598957

APEX nuclease (multifunctional DNA repair enzyme) 1

IDBP-589165

APEX nuclease (multifunctional DNA repair enzyme) 1

IDBP-603902

APEX nuclease (multifunctional DNA repair enzyme) 1

IDBP-597196

APEX nuclease (multifunctional DNA repair enzyme) 1

IDBP-585243

APEX nuclease (multifunctional DNA repair enzyme) 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5\' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:20455191-20457772

Strand

Forward strand

Band

q11.2

Transcripts

ENST00000216714	ENSP00000216714
ENST00000398030	ENSP00000381111
ENST00000438886	ENSP00000416414
ENST00000555414	ENSP00000451979
ENST00000553681	ENSP00000451327
ENST00000554813
ENST00000556296
ENST00000557344	ENSP00000452137
ENST00000555306
ENST00000553555
ENST00000554325	ENSP00000450604
ENST00000557181	ENSP00000452304
ENST00000555839	ENSP00000452460
ENST00000557159
ENST00000553368	ENSP00000451491
ENST00000556054	ENSP00000451170
ENST00000557054	ENSP00000452212
ENST00000557592	ENSP00000451060
ENST00000557365
ENST00000557150	ENSP00000452418

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	88 [view]
Protein-Protein	83 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0004520	endodeoxyribonuclease activity
GO:0004521	endoribonuclease activity
GO:0004523	RNA-DNA hybrid ribonuclease activity
GO:0004528	phosphodiesterase I activity
GO:0004844	uracil DNA N-glycosylase activity
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0008311	double-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0008408	3'-5' exonuclease activity
GO:0016491	oxidoreductase activity
GO:0016890	site-specific endodeoxyribonuclease activity, specific for altered base
GO:0031490	chromatin DNA binding
GO:0032403	protein complex binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0051059	NF-kappaB binding

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0000738	DNA catabolic process, exonucleolytic
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006310	DNA recombination
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007568	aging
GO:0010243	response to organonitrogen compound
GO:0014912	negative regulation of smooth muscle cell migration
GO:0042493	response to drug
GO:0043488	regulation of mRNA stability
GO:0045454	cell redox homeostasis
GO:0045739	positive regulation of DNA repair
GO:0055114	oxidation-reduction process
GO:0070301	cellular response to hydrogen peroxide
GO:0071320	cellular response to cAMP
GO:0071375	cellular response to peptide hormone stimulus
GO:0071417	cellular response to organonitrogen compound
GO:0080111	DNA demethylation
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005813	centrosome
GO:0005840	ribosome
GO:0016607	nuclear speck
GO:0048471	perinuclear region of cytoplasm