Version 5.4
Homo sapiens Gene: SLCO1A2
Summary
InnateDB Gene IDBG-22602.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLCO1A2
Gene Name solute carrier organic anion transporter family, member 1A2
Synonyms OATP; OATP-A; OATP1A2; SLC21A3
Species Homo sapiens
Ensembl Gene ENSG00000084453
Encoded Proteins
IDBP-22606
solute carrier organic anion transporter family, member 1A2
IDBP-369139
solute carrier organic anion transporter family, member 1A2
IDBP-369142
solute carrier organic anion transporter family, member 1A2
IDBP-369145
solute carrier organic anion transporter family, member 1A2
IDBP-369149
solute carrier organic anion transporter family, member 1A2
IDBP-369151
solute carrier organic anion transporter family, member 1A2
IDBP-369158
solute carrier organic anion transporter family, member 1A2
IDBP-369161
solute carrier organic anion transporter family, member 1A2
IDBP-369163
solute carrier organic anion transporter family, member 1A2
IDBP-369167
solute carrier organic anion transporter family, member 1A2
IDBP-369168
solute carrier organic anion transporter family, member 1A2
IDBP-369169
solute carrier organic anion transporter family, member 1A2
IDBP-587731
solute carrier organic anion transporter family, member 1A2
IDBP-589116
solute carrier organic anion transporter family, member 1A2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:21264600-21419594
Strand Reverse strand
Band p12.1
Transcripts
ENST00000307378 ENSP00000305974
ENST00000458504 ENSP00000394854
ENST00000413682 ENSP00000403638
ENST00000422327 ENSP00000416190
ENST00000453443 ENSP00000409314
ENST00000421294 ENSP00000390572
ENST00000450590 ENSP00000407462
ENST00000435179 ENSP00000401195
ENST00000445053 ENSP00000409691
ENST00000421287 ENSP00000390672
ENST00000416627 ENSP00000392124
ENST00000430803 ENSP00000410338
ENST00000480394
ENST00000463718
ENST00000473830
ENST00000544020 ENSP00000440154
ENST00000544290 ENSP00000438348
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0008514 organic anion transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0008206 bile acid metabolic process
GO:0015711 organic anion transport
GO:0015721 bile acid and bile salt transport
GO:0043252 sodium-independent organic anion transport
GO:0044281 small molecule metabolic process
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_23988
Transport of organic anions pathway
REACT_22285
Transport of vitamins, nucleosides, and related molecules pathway
REACT_11042
Recycling of bile acids and salts pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11040
Bile acid and bile salt metabolism pathway
REACT_111217
Metabolism pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
hsa04976
Bile secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9JG34 C9JUW6 C9K059
UniProt Splice Variant
Entrez Gene 6579
UniGene Hs.46440 Hs.630241 Hs.641562 Hs.739392 Hs.740003
RefSeq NM_021094 NM_134431 XM_005253474 XM_005253477
HUGO HGNC:10956
OMIM 602883
CCDS CCDS8686
HPRD 09112
IMGT
EMBL AC006559 AC022224
GenPept
RNA Seq Atlas 6579

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca