InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TOP2B

Summary

InnateDB Gene

IDBG-22611.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TOP2B

Gene Name

topoisomerase (DNA) II beta 180kDa

Synonyms

top2beta; TOPIIB

Species

Homo sapiens

Ensembl Gene

ENSG00000077097

Encoded Proteins

IDBP-22613

topoisomerase (DNA) II beta 180kDa

IDBP-368142

topoisomerase (DNA) II beta 180kDa

IDBP-368148

topoisomerase (DNA) II beta 180kDa

IDBP-368167

topoisomerase (DNA) II beta 180kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:25597905-25664907

Strand

Reverse strand

Band

p24.2

Transcripts

ENST00000264331	ENSP00000264331
ENST00000435706	ENSP00000396704
ENST00000413971	ENSP00000388216
ENST00000424225	ENSP00000391112
ENST00000475717
ENST00000470132
ENST00000491510

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	62 [view]
Protein-Protein	59 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008301	DNA binding, bending
GO:0019899	enzyme binding
GO:0042826	histone deacetylase binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000712	resolution of meiotic recombination intermediates
GO:0000819	sister chromatid segregation
GO:0001764	neuron migration
GO:0006200	ATP catabolic process
GO:0006265	DNA topological change
GO:0006268	DNA unwinding involved in DNA replication
GO:0006312	mitotic recombination
GO:0007409	axonogenesis
GO:0030900	forebrain development
GO:0044774	mitotic DNA integrity checkpoint

Cellular Component

GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000017485

View Gene Order

ENSBTAG00000004593

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

H7BZ82

UniProt Splice Variant

Entrez Gene

7155

UniGene

Hs.475733 Hs.614320

RefSeq

NM_001068 XM_005265427

HUGO

HGNC:11990

OMIM

126431

CCDS

CCDS46776

HPRD

00537

IMGT

EMBL

AC093416

GenPept

RNA Seq Atlas

7155