Version 5.4
Homo sapiens Gene: CCL26
Summary
InnateDB Gene IDBG-22717.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCL26
Gene Name chemokine (C-C motif) ligand 26
Synonyms IMAC; MIP-4a; MIP-4alpha; SCYA26; TSC-1
Species Homo sapiens
Ensembl Gene ENSG00000006606
Encoded Proteins
IDBP-22719
chemokine (C-C motif) ligand 26
IDBP-240638
chemokine (C-C motif) ligand 26
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:75769533-75789896
Strand Reverse strand
Band q11.23
Transcripts
ENST00000005180 ENSP00000005180
ENST00000394905 ENSP00000378365
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0030335 positive regulation of cell migration
GO:0030838 positive regulation of actin filament polymerization
GO:0032855 positive regulation of Rac GTPase activity
GO:0060326 cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04062
Chemokine signaling pathway pathway
INOH
PID NCI
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt Q9Y258
TrEMBL
UniProt Splice Variant
Entrez Gene 10344
UniGene Hs.131342
RefSeq NM_006072 XM_006715837
HUGO HGNC:10625
OMIM 604697
CCDS CCDS5578
HPRD 05262
IMGT
EMBL AB010447 AB016542 AC005102 AF096296 AF124601 AF142434 AY358893 BC069394 BC093773 BC101665 CH471220 EF064763
GenPept AAD15411 AAD22197 AAD46495 AAF09265 AAH69394 AAH93773 AAI01666 AAQ89252 ABK41946 BAA36704 BAA84579 EAW71771
RNA Seq Atlas 10344

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca