Version 5.4
Homo sapiens Gene: PLD4
Summary
InnateDB Gene IDBG-22839.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLD4
Gene Name phospholipase D family, member 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166428
Encoded Proteins
IDBP-245344
phospholipase D family, member 4
IDBP-590622
phospholipase D family, member 4
IDBP-586762
phospholipase D family, member 4
IDBP-585486
phospholipase D family, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:104924816-104937790
Strand Forward strand
Band q32.33
Transcripts
ENST00000392593 ENSP00000376372
ENST00000472901
ENST00000472702
ENST00000540372 ENSP00000438677
ENST00000557573 ENSP00000451278
ENST00000553861 ENSP00000451636
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004630 phospholipase D activity
GO:0005515 protein binding
GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006644 phospholipid metabolic process
GO:0006655 phosphatidylglycerol biosynthetic process
GO:0006909 phagocytosis
GO:0008152 metabolic process
GO:0016042 lipid catabolic process
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0032588 trans-Golgi network membrane
GO:0045335 phagocytic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052160
View Gene Order
ENSBTAG00000015160
Not yet available
Pathways
NETPATH
REACTOME
REACT_160158
Role of phospholipids in phagocytosis pathway
REACT_121280
Synthesis of PG pathway
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_6802
Innate Immune System pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_6900
Immune System pathway
REACT_120870
Phospholipid metabolism pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
hsa00565
Ether lipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.407101
RefSeq NM_138790 XM_006720024
HUGO
OMIM
CCDS CCDS9995
HPRD 11230
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca