Version 5.4
Homo sapiens Gene: MYL5
Summary
InnateDB Gene IDBG-228913.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYL5
Gene Name myosin, light chain 5, regulatory
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000215375
Encoded Proteins
IDBP-228915
myosin, light chain 5, regulatory
IDBP-480096
myosin, light chain 5, regulatory
IDBP-479552
myosin, light chain 5, regulatory
IDBP-474967
myosin, light chain 5, regulatory
IDBP-476683
myosin, light chain 5, regulatory
IDBP-475484
myosin, light chain 5, regulatory
IDBP-483312
myosin, light chain 5, regulatory
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the myosin light chains, a component of the hexameric ATPase cellular motor protein myosin. Myosin is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene product, one of the regulatory light chains, is expressed in fetal muscle and in adult retina, cerebellum, and basal ganglia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:673580-682033
Strand Forward strand
Band p16.3
Transcripts
ENST00000400159 ENSP00000383023
ENST00000506838 ENSP00000427153
ENST00000505477 ENSP00000423118
ENST00000503300 ENSP00000424528
ENST00000502720
ENST00000511290 ENSP00000425162
ENST00000513662 ENSP00000423053
ENST00000507804 ENSP00000427317
ENST00000503612
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0008307 structural constituent of muscle
Biological Process
GO:0006937 regulation of muscle contraction
Cellular Component
GO:0005859 muscle myosin complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa04510
Focal adhesion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.410970 Hs.739122
RefSeq NM_002477 XM_005272277 XM_006713887
HUGO
OMIM
CCDS CCDS43197
HPRD 01182
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca