Version 5.4
Homo sapiens Gene: PEX26
Summary
InnateDB Gene IDBG-229866.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEX26
Gene Name peroxisomal biogenesis factor 26
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000215193
Encoded Proteins
IDBP-1126
peroxisomal biogenesis factor 26
IDBP-229870
peroxisomal biogenesis factor 26
IDBP-361209
peroxisomal biogenesis factor 26
IDBP-594945
peroxisomal biogenesis factor 26
IDBP-810316
peroxisomal biogenesis factor 26
IDBP-810319
peroxisomal biogenesis factor 26
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the peroxin-26 gene family. It is probably required for protein import into peroxisomes. It anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Defects in this gene are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:18077920-18131138
Strand Forward strand
Band q11.21
Transcripts
ENST00000329627 ENSP00000331106
ENST00000399744 ENSP00000382648
ENST00000428061 ENSP00000412441
ENST00000474897 ENSP00000434235
ENST00000610387 ENSP00000482091
ENST00000618979 ENSP00000483492
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0032403 protein complex binding
GO:0051117 ATPase binding
Biological Process
GO:0016558 protein import into peroxisome matrix
GO:0045046 protein import into peroxisome membrane
Cellular Component
GO:0005777 peroxisome
GO:0005779 integral component of peroxisomal membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000067825
View Gene Order
ENSBTAG00000011826
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001127649 NM_001199319 NM_017929
HUGO
OMIM
CCDS CCDS13750 CCDS56221
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca