InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LDHB

Summary

InnateDB Gene

IDBG-23010.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LDHB

Gene Name

lactate dehydrogenase B

Synonyms

HEL-S-281; LDH-B; LDH-H; LDHBD; TRG-5

Species

Homo sapiens

Ensembl Gene

ENSG00000111716

Encoded Proteins

IDBP-23012

lactate dehydrogenase B

IDBP-238250

lactate dehydrogenase B

IDBP-238252

lactate dehydrogenase B

IDBP-369333

lactate dehydrogenase B

IDBP-590586

lactate dehydrogenase B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:21635342-21757857

Strand

Reverse strand

Band

p12.1

Transcripts

ENST00000350669	ENSP00000229319
ENST00000396076	ENSP00000379386
ENST00000396075	ENSP00000379385
ENST00000450584	ENSP00000398015
ENST00000470985
ENST00000470280
ENST00000542765
ENST00000539782	ENSP00000442680
ENST00000544151
ENST00000535112

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	69 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004457	lactate dehydrogenase activity
GO:0004459	L-lactate dehydrogenase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0019900	kinase binding
GO:0042802	identical protein binding
GO:0051287	NAD binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006089	lactate metabolic process
GO:0006090	pyruvate metabolic process
GO:0006096	glycolytic process
GO:0019674	NAD metabolic process
GO:0044237	cellular metabolic process
GO:0044262	cellular carbohydrate metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process