Version 5.4
Homo sapiens Gene: PHB2
Summary
InnateDB Gene IDBG-230632.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHB2
Gene Name prohibitin 2
Synonyms BAP; Bap37; BCAP37; p22; PNAS-141; REA
Species Homo sapiens
Ensembl Gene ENSG00000215021
Encoded Proteins
IDBP-230634
prohibitin 2
IDBP-365133
prohibitin 2
IDBP-603929
prohibitin 2
IDBP-589338
prohibitin 2
IDBP-593061
prohibitin 2
IDBP-807853
prohibitin 2
IDBP-593539
prohibitin 2
IDBP-603397
prohibitin 2
IDBP-601996
prohibitin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:6965327-6970825
Strand Reverse strand
Band p13.31
Transcripts
ENST00000399433 ENSP00000382362
ENST00000440277 ENSP00000412856
ENST00000537646
ENST00000543465
ENST00000546111 ENSP00000438634
ENST00000535923 ENSP00000441875
ENST00000542912 ENSP00000440317
ENST00000545555 ENSP00000475382
ENST00000545167 ENSP00000441662
ENST00000544888 ENSP00000438068
ENST00000536316 ENSP00000439029
ENST00000544134
ENST00000546217
ENST00000542294
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 95 [view]
Protein-Protein 95 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030331 estrogen receptor binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0033600 negative regulation of mammary gland epithelial cell proliferation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0060744 mammary gland branching involved in thelarche
GO:0060749 mammary gland alveolus development
GO:0060762 regulation of branching involved in mammary gland duct morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004264
View Gene Order
ENSBTAG00000013123
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 11331
UniGene
RefSeq NM_001144831 NM_001267700
HUGO HGNC:30306
OMIM 610704
CCDS CCDS53741 CCDS58207
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 11331

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca