Version 5.4
Homo sapiens Gene: PPME1
Summary
InnateDB Gene IDBG-232998.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPME1
Gene Name protein phosphatase methylesterase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000214517
Encoded Proteins
IDBP-64188
protein phosphatase methylesterase 1
IDBP-233052
protein phosphatase methylesterase 1
IDBP-603694
protein phosphatase methylesterase 1
IDBP-591999
protein phosphatase methylesterase 1
IDBP-807380
protein phosphatase methylesterase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:74171099-74254703
Strand Forward strand
Band q13.4
Transcripts
ENST00000328257 ENSP00000329867
ENST00000398427 ENSP00000381461
ENST00000542710
ENST00000544401 ENSP00000438632
ENST00000543525 ENSP00000441498
ENST00000535205
ENST00000541340
ENST00000538501
ENST00000539021
ENST00000617237 ENSP00000484654
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
Experimentally validated
Total 43 [view]
Protein-Protein 42 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004864 protein phosphatase inhibitor activity
GO:0008601 protein phosphatase type 2A regulator activity
GO:0019903 protein phosphatase binding
GO:0051721 protein phosphatase 2A binding
GO:0051722 protein C-terminal methylesterase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006482 protein demethylation
GO:0043086 negative regulation of catalytic activity
GO:0050790 regulation of catalytic activity
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030718
View Gene Order
ENSBTAG00000027612
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.503251 Hs.594805 Hs.674200
RefSeq NM_001271593 NM_016147
HUGO
OMIM
CCDS CCDS44678 CCDS60891
HPRD 17864
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca