Version 5.4
Homo sapiens Gene: ETNK1
Summary
InnateDB Gene IDBG-23439.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ETNK1
Gene Name ethanolamine kinase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139163
Encoded Proteins
IDBP-23441
ethanolamine kinase 1
IDBP-23445
ethanolamine kinase 1
IDBP-600313
ethanolamine kinase 1
IDBP-603998
ethanolamine kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an ethanolamine kinase, which functions in the first committed step of the phosphatidylethanolamine synthesis pathway. This cytosolic enzyme is specific for ethanolamine and exhibits negligible kinase activity on choline. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:22625075-22690665
Strand Forward strand
Band p12.1
Transcripts
ENST00000266517 ENSP00000266517
ENST00000335148 ENSP00000334041
ENST00000538218 ENSP00000446292
ENST00000545979 ENSP00000439614
ENST00000539974
ENST00000544191
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004305 ethanolamine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006646 phosphatidylethanolamine biosynthetic process
GO:0016310 phosphorylation
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030275
View Gene Order
ENSBTAG00000005833
Not yet available
Pathways
NETPATH
REACTOME
REACT_120919
Synthesis of PE pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.29464 Hs.601593
RefSeq NM_001039481 NM_018638
HUGO
OMIM
CCDS CCDS41760 CCDS8698
HPRD 09934
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca