Version 5.4
Homo sapiens Gene: RGS7BP
Summary
InnateDB Gene IDBG-23650.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS7BP
Gene Name regulator of G-protein signaling 7 binding protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186479
Encoded Proteins
IDBP-23652
regulator of G-protein signaling 7 binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and regulates their translocation between the nucleus and the plasma membrane. The encoded protein could be regulated by reversible palmitoylation, which anchors it to the plasma membrane. Depalmitoylation localizes the protein to the nucleus. Polymorphisms in this gene may be associated with risk of aspirin-exacerbated respiratory disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:64506257-64612312
Strand Forward strand
Band q12.3
Transcripts
ENST00000334025 ENSP00000334851
ENST00000508162
ENST00000505263
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0009968 negative regulation of signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021719
View Gene Order
ENSBTAG00000005169
Not yet available
Cross-References
SwissProt Q6MZT1
TrEMBL
UniProt Splice Variant
Entrez Gene 401190
UniGene Hs.657133
RefSeq NM_001029875 NM_001271890 NM_001271891
HUGO HGNC:23271
OMIM 610890
CCDS CCDS34170
HPRD
IMGT
EMBL AC008854 AC035143 AC091862 AK296443 BC140707 BX640900 CH471137
GenPept AAI40708 BAH12357 CAE45947 EAW51372
RNA Seq Atlas 401190

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca