InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LAT

Summary

InnateDB Gene

IDBG-239499.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAT

Gene Name

linker for activation of T cells

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000213658

Encoded Proteins

IDBP-23922

linker for activation of T cells

IDBP-239501

linker for activation of T cells

IDBP-239503

linker for activation of T cells

IDBP-374458

linker for activation of T cells

IDBP-745680

IDBP-745507

IDBP-746939

IDBP-749311

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 12857726

LAT dephosphorylation in human platelets is integrin-mediated and involves PTPN1 protein tyrosine phosphatase and both PTPN1 activation and LAT dephosphorylation processes were involved in the control of irreversible platelet aggregation upon FcgammaRIIa stimulation.

Entrez Gene

Summary

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:28984826-28990783

Strand

Forward strand

Band

p11.2

Transcripts

ENST00000360872	ENSP00000354119
ENST00000354453
ENST00000395461	ENSP00000378845
ENST00000395456	ENSP00000378841
ENST00000454369	ENSP00000398793
ENST00000564277	ENSP00000457036
ENST00000563964
ENST00000570232	ENSP00000455728
ENST00000562701	ENSP00000454793
ENST00000562472
ENST00000566177	ENSP00000456761
ENST00000568440
ENST00000566270

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	66 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0002260	lymphocyte homeostasis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007229	integrin-mediated signaling pathway
GO:0007265	Ras protein signal transduction
GO:0007596	blood coagulation
GO:0009967	positive regulation of signal transduction
GO:0010467	gene expression
GO:0019722	calcium-mediated signaling
GO:0030168	platelet activation
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042110	T cell activation
GO:0043303	mast cell degranulation
GO:0045087	innate immune response (InnateDB)
GO:0048872	homeostasis of number of cells
GO:0050852	T cell receptor signaling pathway
GO:0050863	regulation of T cell activation

Cellular Component

GO:0001772	immunological synapse
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0008180	COP9 signalosome
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042629	mast cell granule
GO:0045121	membrane raft