InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL8

Summary

InnateDB Gene

IDBG-23954.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL8

Gene Name

interleukin 8

Synonyms

GCP-1; GCP1; IL8; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1

Species

Homo sapiens

Ensembl Gene

ENSG00000169429

Encoded Proteins

IDBP-23956

interleukin 8

IDBP-293725

interleukin 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 17220369

IL8 is produced by airway epithelial cells in response to invading bacteria and mediates airway epithelial defence against bacterial infection via the DUOX1-TACE-TGF-alpha-EGFR signalling pathway.

Entrez Gene

Summary

The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:73740506-73743716

Strand

Forward strand

Band

q13.3

Transcripts

ENST00000307407	ENSP00000306512
ENST00000401931	ENSP00000385908
ENST00000483500

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.

Experimentally validated
Total	85 [view]
Protein-Protein	34 [view]
Protein-DNA	47 [view]
Protein-RNA	4 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005153	interleukin-8 receptor binding
GO:0005515	protein binding
GO:0008009	chemokine activity

Biological Process

GO:0001525	angiogenesis
GO:0002237	response to molecule of bacterial origin
GO:0006928	cellular component movement
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007050	cell cycle arrest
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0019722	calcium-mediated signaling
GO:0030155	regulation of cell adhesion
GO:0030593	neutrophil chemotaxis
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031623	receptor internalization
GO:0034976	response to endoplasmic reticulum stress
GO:0035556	intracellular signal transduction
GO:0042119	neutrophil activation
GO:0044267	cellular protein metabolic process
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045087	innate immune response (InnateDB)
GO:0045091	regulation of retroviral genome replication
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway
GO:0048566	embryonic digestive tract development
GO:0050930	induction of positive chemotaxis
GO:0071222	cellular response to lipopolysaccharide
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0090023	positive regulation of neutrophil chemotaxis