Version 5.4
Homo sapiens Gene: DCLK1
Summary
InnateDB Gene IDBG-24120.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCLK1
Gene Name doublecortin-like kinase 1
Synonyms CL1; CLICK1; DCAMKL1; DCDC3A; DCLK
Species Homo sapiens
Ensembl Gene ENSG00000133083
Encoded Proteins
IDBP-24122
doublecortin-like kinase 1
IDBP-24124
doublecortin-like kinase 1
IDBP-24126
doublecortin-like kinase 1
IDBP-24128
doublecortin-like kinase 1
IDBP-808731
doublecortin-like kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:35768652-36131306
Strand Reverse strand
Band q13.3
Transcripts
ENST00000255448 ENSP00000255448
ENST00000360631 ENSP00000353846
ENST00000379893 ENSP00000369223
ENST00000379892 ENSP00000369222
ENST00000477664
ENST00000486239
ENST00000460982
ENST00000615680 ENSP00000484452
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005057 receptor signaling protein activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001764 neuron migration
GO:0006468 protein phosphorylation
GO:0007399 nervous system development
GO:0007409 axonogenesis
GO:0007417 central nervous system development
GO:0007420 brain development
GO:0009615 response to virus
GO:0016197 endosomal transport
GO:0021952 central nervous system projection neuron axonogenesis
GO:0030900 forebrain development
GO:0035556 intracellular signal transduction
GO:0048675 axon extension
GO:0048813 dendrite morphogenesis
Cellular Component
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000027797
View Gene Order
Cross-References
SwissProt
TrEMBL Q5VZY9
UniProt Splice Variant
Entrez Gene 9201
UniGene Hs.507755 Hs.605020 Hs.607774
RefSeq NM_001195415 NM_001195416 NM_004734 XM_005266592 XM_006719893
HUGO HGNC:2700
OMIM 604742
CCDS CCDS55895 CCDS73561 CCDS9354
HPRD 09202
IMGT
EMBL AL157694 AL157760 AL160392 AL390029
GenPept
RNA Seq Atlas 9201

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca