Version 5.4
Homo sapiens Gene: COG8
Summary
InnateDB Gene IDBG-242959.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COG8
Gene Name component of oligomeric golgi complex 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000213380
Encoded Proteins
IDBP-39043
component of oligomeric golgi complex 8
IDBP-748654
IDBP-750011
IDBP-748205
IDBP-811404
component of oligomeric golgi complex 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is a component of the conserved oligomeric Golgi (COG) complex, a multiprotein complex that plays a structural role in the Golgi apparatus, and is involved in intracellular membrane trafficking and glycoprotein modification. Mutations in this gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:69320140-69339667
Strand Reverse strand
Band q22.1
Transcripts
ENST00000306875 ENSP00000305459
ENST00000564419
ENST00000562595 ENSP00000456705
ENST00000562081 ENSP00000455954
ENST00000567493 ENSP00000464395
ENST00000615447 ENSP00000484442
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0015031 protein transport
Cellular Component
GO:0000139 Golgi membrane
GO:0016020 membrane
GO:0017119 Golgi transport complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031916
View Gene Order
ENSBTAG00000001665
Not yet available
Cross-References
SwissProt
TrEMBL H3BQV3 J3QRV3
UniProt Splice Variant
Entrez Gene 84342
UniGene Hs.130849 Hs.606628 Hs.729729 Hs.732992
RefSeq NM_032382
HUGO HGNC:18623
OMIM 606979
CCDS CCDS10876
HPRD 07374
IMGT
EMBL AC026464
GenPept
RNA Seq Atlas 84342

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca